Research Reports

HEI’s mission is to provide credible science to support environmental regulations and other policy decisions. The results of each HEI-funded project undergo peer-review by outside scientists and the Health Review Committee. The HEI Research Reports contain the Investigator’s Report and the Review Committee’s evaluation of the study, summarized in a Commentary or short Critique.

ISSN 1041-5505 (print) ISSN 2688-6855 (online)

Disposition and Metabolism of Free and Particle-Associated Nitropyrenes After Inhalation

Research Report 2

James A Bond

Michele A Medinsky

James D Sun

1986

Topics:

Diesel Exhaust

Nitro-polynuclear aromatic hydrocarbons, including 1-nitropyrene, are constituents of diesel exhaust. Previous fractionation research has suggested that 1-nitropyrene and various dinitropyrenes may account for 20-50% of the total mutagenicity in the diesel particle extract (DPE). Dr. Bond and colleagues at the Inhalation Toxicology Research Institute examined the biological fate of inhaled 14C-1-nitropyrene (NP) in Fischer-344 rats.

Estimation of Risk of Glucose 6-Phosphate Dehydrogenase Deficient Red Cells to Ozone and Nitrogen Dioxide

Research Report 1

Marie A Amoruso

1985

Topics:

Nitrogen Oxides

Ozone & Oxidants

Acute hemolytic anemia is associated with a deficiency in glucose 6-phosphate dehydrogenase (G6PD), an X-linked inheritable characteristic. Hemolytic anemia is thought to be caused by a depletion of glutathione and other reducing compounds in red blood cells. Dr. Amoruso and colleagues sought to experimentally test the Calabrese hypothesis, which suggests that G6PD-deficient individuals may be at an increased risk of hemolysis during exposure to low levels of oxidants such as ozone.