Nitrogen Oxides

In this issue of Update, read about Ellen Mantus, the new HEI Director of Science; HEI’s timely and targeted 2021 Virtual Conference (Sign Up Now!); five HEI studies underway on COVID-19, air pollution, and health; a transition in HEI’s Global Health program… and more!

Research Report 190 describes a study by Frank Gilliland and colleagues that was funded under HEI’s Accountability research program. The investigators collected air quality data and lung function and respiratory symptoms in three cohorts of children who participated in the Children’s Health Study in Southern California. During the 20-year study period, nearly 20 major policy actions were implemented to reduce pollution from transportation and other sources. Gilliland and colleagues evaluated whether the improved air quality was associated with improved lung function and respiratory symptoms in these children.

This report describes a study evaluating the effects of exposure to diesel exhaust (DE) and nitrogen dioxide (NO₂) on the lower airways and blood of allergic asthmatic participants. The study by Dr. Riedl and colleagues was funded as part of HEI's research program looking at diesel exhaust and other particle exposures and allergic response. The participants were exposed in random order to 100 µg/m³ diesel exhaust or 0.35 ppm nitrogen dioxide for 2 hours, with or without an allergen inhalation challenge. The investigators measured multiple physiologic and pulmonary function endpoints, including specific airway resistance, oxygen saturation, bronchial reactivity, and inflammatory and immunologic endpoints.