Global Health

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Newsletter
Health Effects Institute
2013

This newsletter reports on an expert panel named to review diesel epidemiology studies, two HEI Asia workshops on the global health impact of air pollution, and a meeting of HEI's Research Committee and sponsors reviewing progress and priorities, as well as HEI in the news.

Research Report 174
Junfeng (Jim) Zhang
Tong Zhu
Howard Kipen
Guangfa Wang
Wei Huang
David Rich
Ping Zhu
Yuedan Wang
Shou-En Lu
Pamela Ohman-Strickland
Scott Diehl
Min Hu
Jian Tong
Jicheng Gong
Duncan Thomas
2013

This report describes a study to evaluate a series of aggressive policies intended to reduce local and regional emissions in the greater Beijing metropolitan area leading up to and during the 2008 Olympics. Dr. Junfeng (Jim) Zhang of the University of Medicine and Dentistry of New Jersey and colleagues evaluated the impact of the likely changes in air pollution levels on cardiovascular responses in 125 healthy young participants before, during, and after the Beijing Olympics. The investigators used mixed models and time-series methods to analyze associations between pollutant levels and biomarkers.

Contents: Review of Ultrafine Particles Examines Wide Range of Health Studies; Timely Topics, Great City Highlight HEI Annual Conference; Tool Helps Identify Nanoparticles from Motor Vehicles; Air Pollution Controls During 2008 Beijing Olympics; Science Workshop to Inform European Union Policies; Study Finds Ambient Air Pollution Among Top Global Health Risks; ACES Emissions Testing and Animal Exposures Now Complete

Research Report 171
Isabelle Romieu
Nelson Gouveia
Luis A. Cifuentes
and teams of investigators in Brazil, Chile and Mexico
2012

This report describes the first-ever multicity study to estimate the effect of short-term exposures to particulate matter (PM10) and to ozone on mortality in nine Latin American cities. Led by Dr. Isabelle Romieu in Mexico, in collaboration with Dr. Nelson Gouveia in Brazil and Dr. Luis Cifuentes in Chile, the researchers evaluated mortality from all causes and in different age groups, using a common analytic framework. They analyzed mortality in each city and the region as a whole, and explored two pollutant models in individual cities. They also used two meta-analytic statistical techniques to further analyze the effects from individual cities.

Research Report 170
Chit-Ming Wong
Ari Rabl
Thuan Q Thach
Yuen Kwan Chau
King Pan Chan
Benjamin J Cowling
Hak Kan Lai
Tai Hing Lam
Sarah M McGhee
H Ross Anderson
Anthony J Hedley
2012

This report describes a study to explore the role that specific chemical constituents of particulate air pollution may have played in effects on daily mortality observed after the 1990 Hong Kong restriction on sulfur in fuels. The study was part of HEI's Outcomes Research program, which aims to assess the health impacts of actions taken to improve air quality. Dr. Chit-Ming Wong of the University of Hong Kong and his team also developed methods to estimate the impacts on life expectancy of the 1990 sulfur restriction.

Research Report 169
HEI Collaborative Working Group on Air Pollution, Poverty, and Health in Ho Chi Minh City
2012

This report describes a study to investigate the relationships among daily variations in air pollution in Ho Chi Minh City (HCMC), Vietnam, hospital admissions for acute lower respiratory infections in children under age 5, and poverty. The study was part of HEI's Public Health and Air Pollution in Asia (PAPA) program and is the first study of air quality and health to be performed in Vietnam. The team of investigators, led by Drs. Le Truong Giang, Long Ngo, and Sumi Mehta, collected daily pollutant data for PM10, sulfur dioxide, nitrogen dioxide, and ozone at multiple locations throughout the city and obtained admissions data from the two pediatric hospitals in HCMC. They then performed statistical analysis on the data using Poisson time-series and case–crossover methods.

Contents: Greenbaum Testifies on "Producing Credible Science for Decisions"; New HEI Health Effects Study of Modern Diesel Engine Emissions; Health Outcomes and Biomarkers Studies Approved; Multicity Study in Latin America; Air Pollution and Children's Health in Vietnam; HEI in the News; Communication 17: ACES Exposure Atmosphere; Annual Report Now Available; New Global Burden of Disease Estimates; HEI Investigator Wins Haagen-Smit Prize; Workshop on Assessing Exposure to Pollution from Traffic; IARC Review of Diesel and Gasoline Exhaust

Contents: Effects of Exposure to Diesel Exhaust Particles in Persons with Asthma and Allergy; Workshop Brings Experts Together: Atmospheric Chemists and Health Effects Scientists Meet at HEI to Discuss Common Goals; Symposium Sheds Light on Air Toxics Hot Spots; Wood Stove Changeout Program Brings Some Improvements in Health, Air Quality; Three New HEI Studies Launched: Ozone Exposure and Inflammatory Cells / PM Exposure and Heart Rhythm / Impact of Exposure in Early Life; ACES Reaches Important Milestones; New Investigator

Research Report 163
Frank Kelly
Ben Armstrong
Richard Atkinson
H Ross Anderson
Benjamin Barratt
Sean Beevers
Derek Cook
David Green
Dick Derwent
Ian Mudway
Paul Wilkinson
2011

This report describes a study evaluating the feasibility of studying potential changes in air quality and health associated with the London Low Emission Zone (LEZ), which went into effect in 2008 and restricts entry of older, more polluting vehicles into Greater London. Based on their earlier study of London's Congestion Charging Scheme, Dr. Kelly and colleagues conducted emissions and exposure modeling to estimate the projected effects of LEZ implementation. They also assessed the feasibility of using medical records from private practices to evaluate the relationships between exposure to traffic and indicators of respiratory and cardiovascular disease.

Research Report 155
Frank Kelly
H Ross Anderson
Ben Armstrong
Richard Atkinson
Benjamin Barratt
Sean Beevers
Dick Derwent
David Green
Ian Mudway
Paul Wilkinson
2011

This report describes a study that was funded under HEI's research program aimed at measuring the possible health impacts associated with actions taken to improve air quality (health outcomes research). Dr. Kelly and colleagues used a multifaceted approach to exploring the impact of the Congestion Charging Scheme on air quality, which involved a variety of emissions and exposure modeling techniques, analysis of air monitoring data, and a newly developed assay for the oxidative potential of particulate matter collected on filters at urban backgrounds and roadside monitors.