Publications

This page is a list of publications in reverse chronological order. Please use search or the filters to browse by research areas, publication types, and content types.

Displaying 221 - 230 of 346. Show 10 | 25 | 50 | 100 results per page.

1,3 Butadiene: Cancer, Mutations, and Adducts

Rogene F Henderson
Leslie Recio
Vernon E Walker
Ian A Blair
James A Swenberg
2000
Research Report 92
Air Toxics

As part of the Health Effects Institute's air toxics research program, five independent studies were designed to advance our understanding of the roles of different metabolites in 1,3-butadiene (BD)-induced carcinogenesis and of the differences in sensitivity among species, and to develop methods for identifying and measuring biomarkers. The investigators focused on two BD metabolites (1,2-epoxy-3-butene [BDO] and 1,2,3,4-diepoxybutane [BDO2]) that researchers had suspected may play a role in BD carcinogenesis. The studies were conducted by Dr. Rogene Henderson (Lovelace Respiratory Research Institute), Dr. Leslie Recio (CIIT), Dr. Vernon Walker (New York State Department of Health), Dr. Ian Blair (University of Pennsylvania), and Dr. James Swenberg (University of North Carolina at Chapel Hill).

Mechanisms of Morbidity and Mortality from Exposure to Ambient Air Particles

John J Godleski
Richard L Verrier
Petros Koutrakis
Paul J Catalano
2000
Research Report 91
Particulate Matter

Dr John Godleski and colleagues at Harvard School of Public Health conducted an exploratory study to test the effects of particulate matter exposure in dogs, which share many features of the human cardiovascular system. The investigators hypothesized that particulate matter might affect the animals' cardiac function, leading to arrhythmia, and might induce inflammatory responses and changes in pulmonary mechanical measurements. Twelve dogs were exposed to concentrated ambient particles (CAPs) that were 30 times their level in ambient Boston air.

Aldehydes (Nonanal and Hexanal) in Rat and Human Bronchoalveolar Lavage Fluid After Ozone Exposure

Mark W Frampton
William A Pryor
Rafael Cueto
Christopher Cox
Paul E Morrow
Mark J Utell
1999
Research Report 90
Ozone & Oxidants

Dr. Pryor and colleagues at Louisiana State University developed methods for measuring ozone reaction products in in vitro models of lung lining fluids exposed to ozone and in lung fluids from rats exposed to ozone. During the study, Dr. Mark Frampton of the University of Rochester provided Pryor with lung fluids from humans exposed to air or ozone under controlled conditions. Frampton and colleagues exposed exercising smokers and nonsmokers to filtered air or to 0.22 parts per million (ppm) ozone for four hours.

Diesel Workshop: Building a Research Strategy to Improve Risk Assessment

Health Effects Institute
1999
Communication 7
Diesel Exhaust
Communication 7 contains proceedings from a workshop held in Stone Mountain, GA, March 7–9 1999. The following topics were discussed: Risk Assessments of Diesel Emissions: Framework for Building a Research Strategy; Chemical and Physical Properties of Diesel Engine Emissions; Assessment of Exposure to Diesel Engine Emissions; What Do Published Epidemiology Studies Tell Us About Exposure-Response?; What Will Epidemiology Studies Now Underway Tell Us About Exposure-Response?; What Will Epidemiology Studies Now Underway Tell Us About Exposure-Response?; and Consideration of Health Endpoints Other Than Cancer in Future Risk Assessments of Diesel Emissions.

The Health Effects of Fine Particles: Key Questions and the 2003 Review

Health Effects Institute
1999
Communication 8
Air Pollution
Particulate Matter
Global Health
Report of the Joint Meeting of the EC and HEI, held in Brussels, Belgium, January 14–15 1999. The following topics were discussed: What Are People Exposed To and Where Do Particles Come From? What Is Known About the Health Effects of PM? What New Research Results Are Emerging? and Outstanding Questions and Gaps for 2003 and Beyond.

Reproductive and Offspring Developmental Effects Following Maternal Inhalation Exposure to Methanol in Nonhuman Primates

Thomas Burbacher
1999
Research Report 89
Air Pollution
Air Toxics
Emerging Technologies
Fuels & Fuel Additives

In an effort to improve air quality and decrease dependence on petroleum, alternative fuels such as methanol have been considered to substitute for gasoline or diesel fuel. Methanol is also a candidate to provide the hydrogen for fuel cells. Before people are exposed to increased concentrations of methanol, the potential health effects of such exposures require study. Dr. Burbacher and colleagues of the University of Washington studied the effects of long-term exposure to methanol vapors on metabolism and reproduction in adult female monkeys (Macaca fascicularis) and developmental effects in their offspring, who were exposed prenatally to methanol. 

Morphometric Analysis of Alveolar Responses of F344 Rats to Subchronic Inhalation of Nitric Oxide

Robert R Mercer
1999
Research Report 88
Nitrogen Oxides

In a follow-up study to previous research, Dr. Mercer and colleagues at Duke University exposed three groups of rats continuously for six weeks to 2 or 6 ppm nitric oxide (NO) or to filtered air to learn more about the toxicity of NO so as to compare it with two other important oxidants, ozone and nitrogen dioxide (NO2). At the end of the exposure period he used an electron microscope to measure the number of holes in the alveolar septa and to observe other structural changes, such as in the surface area and the number and type of other abnormalities in the alveolar septa.

Development of Liquid Chromatography–Electrospray Ionization–Tandem Mass Spectrometry Methods for Determination of Urinary Metabolites of Benzene in Humans

Assieh A Melikian
Min Meng
Ray O’Connor
Peifeng Hu
Seth M Thompson
1999
Research Report 87
Air Toxics
Carbon Monoxide
Biological Methods

Dr. Melikian and colleagues at the American Health Foundation developed and validated a novel, practical method for assaying metabolites of benzene in humans methods using a technique known as Liquid Chromatography–Electrospray Ionization–Tandem Mass Spectrometry (LC-ESI-MS/MS) to measure benzene metabolites in human urine.

Diesel Emissions and Lung Cancer: Epidemiology and Quantitative Risk Assessment

Health Effects Institute
1999
Special Report
Diesel Exhaust

A Special Report of the Institute's Diesel Epidemiology Expert Panel. Although epidemiologic data have been used generally to identify the hazards associated with exposure to diesel exhaust, questions remain as to whether the human data can be used to develop reliable estimates of the magnitude of any risk for lung cancer (that is, through quantitative risk assessment [QRA]), and whether new research efforts could provide any additional data needed. In response to such issues, the Health Effects Institute initiated the Diesel Epidemiology Project in 1998.

Statistical Methods for Epidemiologic Studies of the Health Effects of Air Pollution

William Navidi
Duncan Thomas
Bryan Langholz
Daniel Stram
1999
Research Report 86
Air Pollution
Multipollutant Mixtures
Innovation
Statistical Methods

Dr. Navidi and colleagues at the University of Southern California discussed the development of three sophisticated statistical methods that would improve the estimates of the health effects of air pollution obtained from epidemiologic studies. First, they took a standard case-crossover design and introduced a bidirectional element where control data were obtained both before and after the health event of interest.