Publications

This report describes a study to evaluate genotoxic effects of exposure to 1,3-butadiene and its metabolites. 1,3-Butadiene is classified as a human carcinogen via inhalation, but risk assessment is complicated due to differences in metabolism between mice and rats and between males and females. Dr. Walker and colleagues studied mutagenicity in rats and mice of both genders, with a focus on evaluating stereoisomers of 1,3-butadiene metabolites and low exposure concentrations.

This report describes a recent analysis of the original ACS cohort, a large ongoing prospective study of mortality in adults that started in 1982 and has played a central role in the setting of National Ambient Air Quality Standards for fine particulate matter pollution in the U.S. as well as assessments of benefits from PM reduction worldwide. The new study describes for the first time work by Dr.

Research Report 139 describes a study in the Netherlands using data from the ongoing Netherlands Cohort Study (NLCS) on diet and cancer. The study is one of the first to systematically assess longer term exposure and mortality in a well characterized European population; it followed a pilot study of 5000 adults randomly selected from the NLCS cohort conducted by the same team of investigators. For the current study, Dr.

Research Report 138, Health Effects of Real-World Exposure to Diesel Exhaust in Persons with Asthma, is one part of HEI's larger program on the role of particles in exacerbating asthma and other allergic diseases. This report describes a study to evaluate how inhaling air with a high concentration of diesel exhaust from vehicular traffic while walking on a busy street in Central London might affect people who had either mild or moderate asthma. Dr.