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10-1 Cardiovascular Effects of Exposure to Low Levels of Ozone in the Presence or Absence of Other Ambient Pollutants

Status: 
Not Active
Number: 
RFA 10-1

Two types of studies are sought to evaluate cardiovascular and respiratory effects in healthy human volunteers, aged 55 and above. In Phase 1, volunteers will be exposed to ozone alone, at concentrations between 60 and 100 ppb, in a controlled laboratory setting. In Phase 2, volunteers will be exposed to real-world ambient air pollution at sites with ozone concentrations comparable to those used in Phase 1. Interested scientists may apply for Phase 1, Phase 2, or both.
Winter 2010 RFA booklet

How to Apply

This RFA is closed.

Publications from this RFA

Multicenter Ozone Study in oldEr Subjects (MOSES): Part 1. Effects of Exposure to Low Concentrations of Ozone on Respiratory and Cardiovascular Outcomes

Research Report 192 Part 1
Mark W Frampton
John R Balmes
Philip A Bromberg
Paul Stark
Mehrdad Arjomandi
Milan J Hazucha
David Q Rich
Danielle Hollenbeck-Pringle
Nicholas Dagincourt
Neil E Alexis
Peter Ganz
Wojciech Zareba
Maria G Costantini
2017
Topics: 
Air Pollution
Ozone & Oxidants

HEI Research Report 192 describes a multicenter study by John Balmes at the University of California–San Francisco, Phil Bromberg at the University of North Carolina–Chapel Hill, and Mark Frampton at the University of Rochester, New York. The study was designed to test whether ozone has short-term cardiovascular effects at present-day ambient levels. It evaluated respiratory and cardiovascular outcomes in 87 healthy participants (60 years old on average) who were exposed to 0, 70, or 120 ppb ozone for 3 hours while exercising moderately.

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