Research Reports

This report presents the findings of a study led by Manabu Shiraiwa of the University of California, Irvine, a recipient of HEI’s Walter A. Rosenblith New Investigator Award. Shiraiwa and colleagues evaluated the mechanisms of aerosol-induced reactive oxygen species formation by two pathways in the respiratory tract: by chemical reactions  and by immune cells called macrophages.

This study by Dr. George S. Downward and Dr. Roel Vermeulen from Utrecht University, the Netherlands, addresses a clear research gap by leveraging harmonized data from the Asia Cohort Consortium, a large multicenter collaborative research effort in Asia that began in 2008.

This report presents a comprehensive HEI study examining potential health risks from low levels of air pollution exposure in millions of Canadian citizens. Michael Brauer at The University of British Columbia and his colleagues combined satellite data, air monitor sampling, and atmospheric modeling to estimate outdoor PM_2.5 exposures across Canada from 1981 to 2016.

Research Report 211 presents a major HEI study by Dr. Francesca Dominici of the Harvard T.H. Chan School of Public Health and colleagues. The investigators examined the risk of mortality associated with exposure to low ambient air pollution concentrations in a cohort of 68.5 million older Americans.