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14-3 Assessing Health Effects of Long-term Exposure to Low Levels of Ambient Air Pollution

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RFA 14-3

HEI is seeking to fund studies to assess health effects of long-term exposure to low levels of ambient air pollution, including studies to evaluate all-cause and cause-specific mortality and morbidity endpoints. RFA 14-3 solicits studies to analyze and evaluate exposure-response function(s) for PM2.5 and other pollutants at levels currently prevalent in North America, Western Europe and other high-income regions and related questions about adverse health effects at low levels of ambient air pollution. In addition, RFA 14-3 solicits studies to develop methods required for, and specifically suited to, conducting such research. At the outset, HEI expects to fund a small number of large studies for up to 4 years. HEI also expects to fund some smaller-scale methods development studies. Fall 2014 RFA booklet

Read more about the studies funded under this RFA in this Program Summary.

How to Apply

This RFA is closed.

Publications from this RFA

Research Report 203
Michael Brauer
Jeffrey R. Brook
Tanya Christidis
Yen Chu
Dan Crouse
Anders Erickson
Perry Hystad
Chi Li
Randall V Martin
Jun Meng
Amanda J. Pappin
Lauren L. Pinault
Michael Tjepkema
Aaron van Donkelaar
Scott Weichenthal
Richard T Burnett
2019

Research Report 203 describes the first-phase results of a study evaluating the relationship between long-term exposure to low concentrations of PM2.5 and non-accidental mortality, including a characterization of the shape of the concentration–response functions, in a large population-based cohort (~9 million adults) in Canada. The report also presents the detailed Commentary on the study by HEI’s Low-Exposure Epidemiology Studies Review Panel.

Research Report 212
Michael Brauer
Jeffrey R. Brook
Tanya Christidis
Yen Chu
Dan Crouse
Anders Erickson
et al
2022

This report presents a comprehensive HEI study examining potential health risks from low levels of air pollution exposure in millions of Canadian citizens. Michael Brauer at The University of British Columbia and his colleagues combined satellite data, air monitor sampling, and atmospheric modeling to estimate outdoor PM2.5 exposures across Canada from 1981 to 2016.

Research Report 208
Bert Brunekreef
Maciej Strak
Jie Chen
Zorana J Andersen
Richard Atkinson
Mariska Bauwelinck
et al
2021

Research Report 208 presents a study by Bert Brunekreef at the Institute for Risk Assessment Sciences, Utrecht University, the Netherlands, and colleagues examining associations between exposures to relatively low levels of air pollution below the current EU standards and several health outcomes among participants in 22 European cohorts. 
 

Research Report 200
Francesca Dominici
Joel Schwartz
Qian Di
Danielle Braun
Christine Choirat
Antonella Zanobetti
2019

Research Report 200 describes the first-phase results of a study examining any association between exposure to low levels of air pollution — both PM2.5 and O3 — and all-cause mortality in a population of 61 million Medicare enrollees residing in the continental United States. The report also presents the detailed Commentary on the study by HEI’s Low-Exposure Epidemiology Studies Review Panel.

Research Report 211
Francesca Dominici
Antonella Zanobetti
Joel Schwartz
Danielle Braun
Ben Sabath
Xiao Wu
2022

Research Report 211 presents a major HEI study by Dr. Francesca Dominici of the Harvard T.H. Chan School of Public Health and colleagues. The investigators examined the risk of mortality associated with exposure to low ambient air pollution concentrations in a cohort of 68.5 million older Americans.