|
| |
The Health Effects Institute
Annual
Conference 2000
Exploring Exposure and
Risk Issues
April
911, 2000
Emory Conference Center
Atlanta, GA
Program
Rates and Information
Atlanta Convention and Visitors Bureau
Fernbank Museum
of Natural History
HEI Program Coordinators
Maria Costantini
Diane Mundt
Sunday April 9, Morning
Minisymposium
(separate registration required)
Location: Emory Amphitheater
Emerging Technologies in Molecular
Biology and their Application to Environmental Health Issues
Chair: Seymour Garte, Environmental and Occupational Health Sciences
Institute, and HEI Research Committee
An explosion of new technology associated with the Human Genome Project has led to
advances in the fields of genomics (understanding genes and their functions), gene
expression, and proteomics (understanding protein products and their functions). This
minisymposium will introduce some of these molecular biology advances, including their
potential uses and limitations, and discuss how they can further our understanding of the
health impact of environmental exposures.
9:00 am Opening remarks, Seymour Garte
Emerging Technologies
9.10 am Use of microarray technology in the
pharmaceutical industry, Katherine Call, Aventis/Hoechst Corporation
9:50 am Application of genomics to
toxicology, Cynthia Afshari, National Institute for Environmental and Health
Science
Application of New Technologies to Environmental Health Issues
10:30 am Toxicology studies, George
Leikauf, University of Cincinnati Medical Center
10:50 am Transitional epidemiology
studies, Richard Albertini, University of Vermont Medical School
11:10 am Epidemiology studies, Paolo
Boffetta, International Agency for Research on Cancer
11:30 am Concluding remarks, Seymour
Garte
12:00 pm Lunch
Sunday April 9, Afternoon
Session
Location: Emory Amphitheater
1:00 pm Welcome, Dan Greenbaum, President, Health Effects
Institute
Data Access and Availability
Chair: Donald Kennedy, Editor-in-Chief, Science, Stanford University; and HEI
Board of Directors
Leaders from government, science, and industry will discuss why some have sought greater
access to scientific data; identify key, sometimes practical questions and concerns
regarding data access and sharing; and propose constructive solutions to providing access
post Shelby legislation.
1:15 pm Introduction, Donald
Kennedy
1:35 pm Agency Experience and Guidelines,
Wendy Baldwin, National Institutes of Health
2:05 pm Perspective: Industry, Lucinda
Minton Langworthy, Counsel, Hunton and Williams
2:25 pm Perspective: Investigator,
David Savitz, University of North Carolina
2:45 pm General Discussion
3:15 pm Break
3:30 pm Poster
Session I . Air Pollutants: Exposure Assessment, Epidemiology, and Toxicology
Location: Ballroom
5:30 pm Opening Reception
7:00
pm Dinner and Keynote Address: The European Union's Agenda
for Environmental Protection
James Currie, Director
General, DG Environment, European Commission
Location: Ballroom
Monday April 10,
Morning Session
8:30 am The HEI Strategic Plan: 20002005
Dan Greenbaum, President, HEI; Dan Tosteson, Harvard Medical School, and
HEI Review Committee Chair; Bob O'Keefe, Vice President, HEI; and Jane Warren,
Director of Science, HEI
HEI has developed a new strategic plan to provide vision for its efforts in the new
century. In this session, members of the HEI staff and Committees will describe HEIs
future directions and initiatives.
Approaches to Improving Assessment of Exposure to Air
Pollutants
Chairs: Thomas Kensler, Johns Hopkins University and HEI Review Committee; and Robert
Sawyer, University of California, Berkeley, and HEI Research Committee
The difficulty of accurately assessing individual exposure has long been recognized to be
a limitation of epidemiologic studies. This session will focus on methods for improving
our ability to reconstruct or determine personal exposure to air pollutants and for
reducing exposure measurement error. The session is divided into three parts. The first
part will focus on the studies using biomarkers of dose, the second on methods to improve
retrospective assessment of exposure to diesel exhaust, and the third on the exposure
measurement error in epidemiologic studies of particulate matter.
I. Air Toxics Exposure and Biomarkers
9:15 am Relationship between personal
exosure to benzene and urine levels of metabolites, Qingshan Qu and Beverly
Cohen, New York University Medical Center; Assieh Melikian, American Health
Foundation
10:05 am Relationship between routes of exposure
and blood levels of MTBE, James Prah, US Environmental Protection Agency, and
David Ashley, Centers for Disease Control and Prevention
10:40 am Break
II.
Diesel Particulate Emissions and Exposure
11:00 am Changes in particulate emssions over time
in a highway tunnel
Alan Gertler, Desert Research Institute
11:25 am Assessment of the feasibility of
estimating current and past exposure to diesel exhaust
Thomas Smith, Harvard School of Public Health
11:50 am Validation of methods for evaluating
exposure to diesel exhaust
Gurumurthy Ramachandran, University of Minnesota
12:30 pm Lunch
1:00 pm
Luncheon address
Norine Noonan, Assistant Administrator, Office of Research and
Development, U.S. Environmental Protection Agency
Monday April 10,
Afternoon Session
1:30 pm Poster Session II.
Particulate Matter (PM): Epidemiology and Toxicology
Approaches to Improving Assessment of
Exposure to Air Pollutants (Session continued)
Chair: Edo Pellizzari, Research Triangle Institute and HEI Review Committee
III.
PM Personal Exposure Versus Ambient Measurements: Addressing the Problem of Measurement
Error
3:30 pm Personal exposure to fine
particulate matter in elderly subjects: Relation between personal, indoor and outdoor
concentrations, Nicole Janssen, University of Wageningen
4:00 pm Preliminary results of the
Baltimore and Atlanta exposure assessment and health effects studies, Petros Koutrakis,
Harvard School of Public Health
4:30 pm The ARIES study:
Preliminary results and issues related to an ongoing study of air pollution and health in
Atlanta, Ronald Wyzga, Electric Power Research Institute
5:00 pm Concluding Remarks, Thomas
A. Louis, University of Minnesota
5:30 pm Adjourn
5:50 pm Buses leave for Fernbank Museum of Natural History
6:00 pm Reception
and Dinner
8:45 pm Buses leave for
Emory Conference Center Hotel
Tuesday April 11
Morning Session
The State of PM Regulation in the U.S. and Europe - EPA's PM Criteria
Document and WHO PM Guidelines
This session will offer the opportunity to learn more about the status of PM regulation in
the U.S. and worldwide.
8:30 am An Update on the
review and implementation of the PM National Air Quality Standards
John Bachman, U.S. Environmental Protection Agency
9:00 am WHO Air Quality
Guidelines for Europe: Air pollution control in the context of transport and health
Dieter
Schwela, World Health Organization, Geneva
National Mortality and Morbidity Air Pollution Study (NMMAPS)
Chair: Gerald van Belle, University of Washington and HEI Research Committee
NMMAPS is a nationwide epidemiologic study of air pollution and daily morbidity and
mortality in 90 U.S. cities. The NMMAPS investigators have also developed methods to
estimate reduced in life expectancy associated with short-term exposure to air pollution
and to quantify the impact of errors in air pollution exposure measurements on the
estimated association of air pollution with daily mortality. In this session,
investigators, members of the NMMAPS Oversight Committee, and members of the HEI Review
Committee will present and discuss the complete results of the analyses.
9:30 am
Introduction, Gerald van Belle
9:40 am
Presentation of results on morbidity and mortality, Jonathan Samet, Scott Zeger,
and Francesca Dominici, Johns Hopkins University; Douglas Dockery and Joel
Schwartz, Harvard School of Public Health
10:20 am Break
10:40 am Presentation of Results
on Morbidity and Mortality (continued)
11:00 am Comments from the HEI NMMAPS Review Panel and
perspective on the future of epidemiological research on acute effects of air pollution, Sverre
Vedal, University of British Columbia, NMMAPS Review Panel, and HEI Review Committee
11:20 am General Discussion
12:00 pm Lunch
Tuesday April 11 Afternoon Session
The HEI Epidemiology
Reanalysis Project
Chair: Arthur Upton, Environmental & Occupational Health Sciences Institute
and Chair of the HEI Epidemiology Reanalysis Project Expert Panel
The Epidemiology Reanalysis Project is an independent reanalysis of the Harvard Six-Cities
and American Cancer Society studies of fine particulate air pollution and mortality. The
project objectives are: 1) to validate the published results of the two studies by
conducting quality assurance on samples of the original data sets and attempting to
reproduce the original results and 2) to conduct sensitivity analyses to test the
robustness of the original findings and the interpretation to alternative analytic
approaches. In this session, investigators and members of the HEI Expert Panel overseeing
the project study will present results of both the validation and the sensitivity
analyses.
1:00 pm Key scientific issues
in the Reanalysis of the Harvard Six Cities and American Cancer Society studies
Clarice Weinberg, National Institute of Environmental Health Sciences and HEI
Epidemiology Reanalysis Project Expert Panel
1:20 pm Preliminary
Results, Daniel Krewski and Rick Burnett, University of Ottawa
2:10 pm Comments from the
Review Panel, Millicent Higgins, University of Michigan and Chair, HEI
Epidemiology Reanalysis Review Panel
2:30 pm General Discussion
3:25 pm Closing Remarks, Dan Greenbaum
3:30 pm Conference Adjourns
Meeting Rates*
(hotel not included)
Full Conference
......................................................................................................$440
Sunday afternoon through Tuesday (includes all meals, Sunday lunch through Tuesday lunch)
Single Day Rates
- Sunday Includes lunch, break, reception and dinner........... ...$140
- Monday Includes three meals, breaks and reception..............$180
- Tuesday Includes breakfast, break and
lunch........................$120
- Day Rates including breaks and lunch
only.............................$80
*Please contact HEI for U.S. Government rates
For registration form and further information:
Gail Allosso
Health Effects Institute
955 Massachusetts Avenue
Cambridge, MA 02139, USA
telephone: +1-617-876-6700
fax: +1-617-876-6709
E-mail: gallosso@healtheffects.org
Home | About HEI | What's New? |
Newsletter | HEI International | Publications
Research | Funding
| Meetings | Contact HEI | Links |
Search | Site Map
Copyright © 2010 Health Effects Institute. Please send
comments to webmaster@healtheffects.org
|